Published Studies

Our published articles showcase our innovative products and cutting-edge technologies.

RhinoChill & BrainCool System

Busch H.J. et al. Safety and feasibility of nasopharyngeal evaporative cooling in the emergency department setting in survivors of cardiac arrest. Resuscitation 81, 943–949 (2010).
Castren M. et al. Intra-arrest transnasal evaporative cooling: A randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation 122, 729–736 (2010).
Abou-Chebl A. et al. Local brain temperature reduction through intranasal cooling with the RhinoChill device: Preliminary safety data in brain-injured patients. Stroke 42, 2164–2169 (2011).
Poli S. et al. Safety evaluation of nasopharyngeal cooling (RhinoChill®) in stroke patients: An observational study. Neurocrit. Care 20(1): p. 98-105 (2014b).
Poli S. et al. Rapid Induction of COOLing in Stroke Patients (iCOOL1): A randomised pilot study comparing cold infusions with nasopharyngeal cooling. Crit. Care 18(5): p. 582 (2014a).
Nordberg P. et al. Transnasal evaporative cooling in healthy awake persons. Resuscitation 96, 125(2015).
Vanderpol J et al. Therapeutic effect of intranasal evaporative cooling in patients with migraine: A pilot study. J. Headache Pain 16, 5 (2015).
Islam S. et al. Early targeted brain COOLing in the cardiac CATHeterisation laboratory following cardiac arrest (COOLCATH). Resuscitation 97, 61–67 (2015).
Zughaft D.J.L. et al. Safety, feasibility, and hemodynamic effects of mild hypothermia in transcatheter aortic valve replacement: The TAVR-CHILL trial. Ther. Hypothermia Temp. Manag. 5, 209–216 (2015).
Grave M.S. et al. Safety and feasibility of the RhinoChill immediate transnasal evaporative cooling device during out-of-hospital cardiopulmonary resuscitation. Medicine (Baltimore) 95,e4692 (2016).
Nordberg P. et al. Effect of trans-nasal evaporative intra-arrest cooling on functional neurologic outcome in out-of-hospital cardiac arrest: The PRINCESS randomized clinical trial. JAMA 7;321(17): 1677-1685 (2019).
Awad A. et al. Time to intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest patients and its association with neurologic outcome: A propensity matched sub-analysis of the PRINCESS trial. IntensiveCare Med. 46(7):1361-1370 (2020).
Taccone F.S. et al. Effect of intra-arrest trans-nasal evaporative cooling inout-of-hospital cardiac arrest: a pooled individual participant data analysis. Crit.Care 25, 198 (2021).
Bardutzky J. et al. COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS) – A pilot study. Submitted to the Journal of Stroke Vascular Neurology.
Taccone F.S. et al. A pooled analysis of individual patient data comparing intra-arrest cooling in out-of-hospital cardiac arrest patients with shockable and non-shockable rhythms. In preparation for the Journal of American Heart Association.
Awad A. et al. The importance of time to cooling in out-of-hospital cardiac arrest patients to influence neurologically intact survival: A sub-analysis of the PRINCESS trial. In preparation for the Journal of Resuscitation.
Kollmar A. et al. The combination of RhinoChill and BrainCool in the context of a therapeutic, controlled hypothermia after frustran mechanical thrombectomy - a case series. Presented at DIVI Congress (2019).

Cooral System

Mahdi A. et al. Can cryoprevention of oral mucositis be obtained at a higher temperature? Clin. Oral Invest. 25, 4519–4526 (2021).
Walladbegi J. et al. Efficacy of a novel device for cryoprevention of oral mucositis: A randomized, blinded, multicenter, parallel group, phase 3 trial. Bone Marrow Transplant 57, 191–197 (2022).

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